Endocrine Abstracts

Orexins, the novel pluripotent hypothalamic peptides, have been shown to exert important roles in the regulation of multiple physiological functions and behaviors including appetite, sleep and wakefulness and energy homeostasis through neural and endocrine mechanisms. Evidence emerging from recent research indicates that orexins may be involved in many other physiological functions. Our previous results have suggested that orexin-A and B activate Ca2+ signaling in c...

Chronic central administration of KiSS-1 peptide to immature female rats induces pubertal maturation, characterized by advanced vaginal opening, increased uterine and ovarian weights, elevated levels of luteinizing hormone (LH) and estrogen. There is evidence that the pineal gland may be also involved in puberty onset because melatonin secretion declines near puberty. We have investigated whether there is an interaction between kisspeptin and melatonin in timing of puberty ons...

Purpose: Asprosin is a novel glucogenic adipokine produced by the fibrillin 1 (FBN1) gene that is generated and released by white adipose tissue during fasting. Asprosin hormone has been shown to improve the sense of smell in wild-type mice by activating the OLFR734 receptor and decreasing the time it takes for them to discover hidden food. The purpose of this study was to determine the effects of asprosin on the sense of smell in female rats through the use of a hidden cookie...